Aprepitant 125mg/80mg Capsule Kit

Product Introduction

Aprepitant 125mg/80mg Capsule Kit is an antiemetic treatment for preventing nausea and vomiting caused by cancer chemotherapy. It is used with other anti-sickness medicines to cover both the early and delayed phases of chemotherapy-induced symptoms.

How to use

The usual three-day oral regimen uses 125mg on day 1 and 80mg on days 2 and 3, with or without food. Take the daily dose one hour before chemotherapy; on days without chemotherapy, take it in the morning. The accompanying antiemetic and steroid schedule is part of the same regimen.

How it works

Aprepitant blocks neurokinin-1 receptors in the brain, preventing substance P from activating vomiting pathways. This complements serotonin-blocking antiemetics, which act through a different receptor system.

Side effects

Hiccups, fatigue, reduced appetite, indigestion, constipation and headache can occur. Serious allergic reactions are uncommon. Severe rash, swelling or breathing difficulty requires immediate treatment.

Important information

Aprepitant affects CYP3A4 and CYP2C9, creating interactions with medicines such as dexamethasone and warfarin. Hormonal contraception can be less effective during treatment and for one month afterwards, so use an effective alternative or backup method during that interval. Pimozide is an important incompatible medicine.