Venetoclax 100mg Tablets$51.00
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Venetoclax 100mg Tablets
SKU GME1104Oncology Care
Product Introduction
Venetoclax 100mg is a targeted treatment for chronic lymphocytic leukaemia and small lymphocytic lymphoma. It is also used with other medicines for newly diagnosed acute myeloid leukaemia in older adults or people unable to receive intensive induction chemotherapy.
How to use
Take the daily tablet dose with a meal and water. Treatment begins with a stepwise dose increase, with blood tests and a hydration plan around dose changes. Swallow the tablets whole; do not independently alter an established formulation or restart a previous dose after an interruption.
How it works
Venetoclax inhibits BCL-2, a protein that helps abnormal blood cells avoid programmed cell death. Blocking BCL-2 restores this cell-death pathway in susceptible cancer cells.
Side effects
Low neutrophils, anaemia, low platelets, nausea, diarrhoea and fatigue are common. Tumour lysis syndrome can cause dangerous electrolyte changes and kidney injury. Fever, chills, reduced urine, confusion or an irregular heartbeat needs urgent assessment.
Important information
Kidney function, tumour burden, uric acid and electrolytes determine tumour-lysis precautions. Strong CYP3A inhibitors are incompatible with the CLL/SLL ramp-up phase, and later treatment can require major dose adjustments.
Uses
- CLL/SLL
- combination treatment of newly diagnosed AML in older adults or those unable to receive intensive induction chemotherapy.
Benefits
Targeting an abnormal cell-survival mechanism can produce deep responses in susceptible blood cancers. Appropriate combinations and carefully managed dose escalation improve the balance between disease control and treatment toxicity.
Why does treatment start at a low dose and build up?
Rapid destruction of many cancer cells can overwhelm the kidneys with breakdown products. Gradual escalation and timed blood tests reduce the risk of tumour lysis syndrome.
Which fruits should I avoid while taking venetoclax?
Avoid grapefruit and grapefruit juice, Seville oranges and starfruit. They can slow venetoclax breakdown and raise its level, increasing toxicity.
What happens if treatment is interrupted?
The tumour-lysis risk may need to be reassessed before restarting. A previous full dose is not automatically the correct restart dose, especially during early escalation.
Why do antifungal medicines matter during treatment?
Several azole antifungals strongly inhibit CYP3A and can sharply raise venetoclax exposure. The exact antifungal and treatment phase determine whether it is avoided or the venetoclax dose is reduced.
BCL-2: protein that prevents programmed cell death. Apoptosis: controlled cell death. Ramp-up: planned stepwise dose increase. Tumour lysis syndrome: metabolic complications from rapid cancer-cell breakdown. Neutropenia: low infection-fighting white-cell count.; AR: Venetoclax 100mg أقراص; FR: Venetoclax 100mg comprimés; PT: Venetoclax 100mg comprimidos; ES: Venetoclax 100mg comprimidos; RU: Venetoclax 100mg таблетки; ID: Venetoclax 100mg tablet; VI: Venetoclax 100mg viên nén; MS: Venetoclax 100mg tablet; TL: Venetoclax 100mg tableta; ZH-SG: Venetoclax 100mg 片剂