Trametinib 0.5mg Tablets$796.00
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$796.00 each
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8% off
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Trametinib 0.5mg Tablets
SKU GME1122Oncology Care
Product Introduction
Trametinib 0.5mg is a targeted MEK inhibitor used for cancers with susceptible BRAF mutations, including melanoma. It is often combined with dabrafenib, with the mutation and cancer type determining the treatment combination.
How to use
Take the tablet dose once daily on an empty stomach, at least one hour before or two hours after a meal. Swallow the tablets whole without crushing or breaking them. When combined with dabrafenib, the trametinib dose can be aligned with one of the two daily dabrafenib doses.
How it works
Trametinib inhibits MEK1 and MEK2 within the MAPK signalling pathway. This blocks growth signals downstream of BRAF and can slow division of susceptible cancer cells.
Side effects
Rash, diarrhoea, fatigue, swelling and, particularly in combination, fever can occur. Serious effects include reduced heart-pumping function, retinal problems, lung inflammation and bleeding. Sudden vision changes or new breathlessness needs urgent assessment.
Important information
Heart function is assessed before treatment and at intervals during therapy. Eye symptoms require prompt examination rather than waiting for a routine visit.
Uses
- Selected BRAF V600-mutated melanoma and other eligible BRAF-mutated cancers within the appropriate single-agent or dabrafenib-containing regimen.
Benefits
MEK inhibition can improve control of susceptible tumours. Blocking two points in the BRAF/MEK pathway with combination treatment can improve disease control compared with BRAF inhibition alone in appropriate settings.
Can I put trametinib tablets into a weekly pill organiser?
Keep these tablets in their original container, protected from moisture, rather than transferring them to a pill organiser. Retain the desiccant where supplied. This presentation is stored refrigerated at 2–8°C.
Why can an eye examination be urgent?
MEK inhibition can affect the retina, including causing fluid accumulation or a retinal-vein blockage. New blurred vision, loss of vision or eye pain should be assessed promptly.
What should I do if the next dose is less than 12 hours away?
Skip the missed dose and take the next dose at the regular time. If vomiting follows a dose, do not take a replacement tablet that day.
Why is a heart scan needed if I have no heart symptoms?
A fall in left-ventricular function can occur before obvious symptoms. Baseline and repeat measurements can identify a treatment-related change early.
MEK1/2: enzymes carrying signals in the MAPK growth pathway. BRAF mutation: genetic change that can activate tumour growth. Ejection fraction: proportion of blood pumped out by the heart with each beat. Retina: light-sensitive tissue at the back of the eye. Targeted therapy: treatment directed at a cancer-related molecule.; AR: Trametinib 0.5mg أقراص; FR: Trametinib 0.5mg comprimés; PT: Trametinib 0.5mg comprimidos; ES: Trametinib 0.5mg comprimidos; RU: Trametinib 0.5mg таблетки; ID: Trametinib 0.5mg tablet; VI: Trametinib 0.5mg viên nén; MS: Trametinib 0.5mg tablet; TL: Trametinib 0.5mg tableta; ZH-SG: Trametinib 0.5mg 片剂