Thiotepa 100mg Injection

Product Introduction

Thiotepa 100mg is an alkylating chemotherapy used in selected cancer regimens and in conditioning before haematopoietic stem-cell transplantation. The route and intensity depend on the treatment protocol.

How to use

For transplant conditioning it is prepared and given by controlled intravenous infusion. Follow the treatment-unit bathing and clothing-change schedule because thiotepa and its metabolites can be excreted in sweat.

How it works

Thiotepa and its active metabolite form DNA cross-links, damaging rapidly dividing malignant cells and suppressing marrow cells before transplantation.

Side effects

Low blood counts, mouth inflammation, nausea, diarrhoea, rash and liver-test abnormalities can occur. Severe infection and neurological toxicity are important risks with intensive treatment.

Important information

Skin folds and areas under dressings need particular care during high-dose treatment. Other administration routes are protocol-specific and must not be substituted for an intravenous conditioning regimen.