Sunitinib Malate 12.5mg Capsules

Product Introduction

Sunitinib Malate 12.5mg is a multi-targeted kinase inhibitor used in selected kidney cancers, gastrointestinal stromal tumours and pancreatic neuroendocrine tumours. It acts on both tumour-cell signalling and tumour blood-vessel growth.

How to use

Swallow the capsules whole at a consistent time, with or without food. Some regimens use 4 weeks of treatment followed by 2 weeks off; others use continuous daily treatment. Use the schedule for the specific tumour setting.

How it works

Sunitinib inhibits several receptor tyrosine kinases, including VEGF and PDGF receptors, reducing growth and angiogenesis signals.

Side effects

Fatigue, diarrhoea, mouth soreness, hand-foot reactions, high blood pressure and low blood counts can occur. Liver injury and impaired heart function are important risks.

Important information

Blood pressure, thyroid function, blood counts and liver tests may be monitored. Avoid grapefruit. Planned surgery and non-healing wounds require attention because wound healing can be impaired.