Pitolisant 4.45mg Tablets$28.00
1–9 boxes
$28.00 each
10–24 boxes
8% off
25+ boxes
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Pitolisant 4.45mg Tablets
SKU GME1488Sleep Care
Product Introduction
Pitolisant 4.45mg is a histamine-3 receptor antagonist/inverse agonist used for excessive daytime sleepiness and cataplexy associated with narcolepsy. It promotes wakefulness through histamine signalling rather than replacing normal sleep.
How to use
Take the scheduled dose once each morning on waking, with or without food. The dose is increased gradually according to response and tolerance. If a dose is missed, resume the next morning rather than taking it late in the day.
How it works
Pitolisant blocks inhibitory H3-receptor activity and increases histamine signalling in the brain, supporting wakefulness.
Side effects
Insomnia, headache, nausea and anxiety can occur. QT prolongation is an important risk in susceptible patients.
Important information
Kidney or liver impairment and QT-prolonging medicines affect dose suitability. Hormonal contraceptive effectiveness can be reduced; use a non-hormonal method during treatment and for at least 21 days afterwards.
Uses
- Narcolepsy-associated excessive daytime sleepiness and cataplexy in eligible patients.
Benefits
Can improve daytime alertness and reduce cataplexy frequency as part of narcolepsy care.
Is the full benefit expected after the first tablet?
No. Dose titration and several weeks of treatment may be needed to assess the response.
Why can some antihistamines reduce its effect?
Sedating H1 antihistamines oppose histamine-related wakefulness and may reduce benefit.
Does feeling more alert guarantee that driving is safe?
No. Residual sleepiness and individual response still need assessment before driving or hazardous work.
What is cataplexy?
It is a brief loss of muscle tone, often triggered by emotion, that can occur in narcolepsy while awareness is preserved.
Narcolepsy: a disorder affecting control of sleep and wakefulness. Cataplexy: emotion-triggered loss of muscle tone. H3 receptor: a receptor regulating histamine release.; AR: Pitolisant 4.45mg أقراص; FR: Pitolisant 4.45mg comprimés; PT: Pitolisant 4.45mg comprimidos; ES: Pitolisant 4.45mg comprimidos; RU: Pitolisant 4.45mg таблетки; ID: Pitolisant 4.45mg tablet; VI: Pitolisant 4.45mg viên nén; MS: Pitolisant 4.45mg tablet; TL: Pitolisant 4.45mg mga tableta; ZH-SG: Pitolisant 4.45mg 片剂