Palbociclib 100mg Capsules

Product Introduction

Palbociclib 100mg is a targeted treatment used with endocrine therapy for hormone receptor-positive, HER2-negative advanced or metastatic breast cancer. It is part of a combination regimen rather than a stand-alone replacement for hormonal treatment.

How to use

Take the capsule dose once daily with food, usually for 21 consecutive days followed by a seven-day break in a 28-day cycle. Swallow capsules whole without opening or crushing them.

How it works

Palbociclib inhibits cyclin-dependent kinases 4 and 6. These enzymes help move cells through the growth cycle; blocking them slows division of susceptible hormone-driven breast-cancer cells.

Side effects

Reduced neutrophils or other blood cells, fatigue, mouth sores, nausea, diarrhoea and hair thinning can occur. Fever can indicate infection during neutropenia. New persistent cough or breathlessness may signal uncommon lung inflammation.

Important information

A full blood count is checked before treatment, at cycle starts and during early cycles. Strong CYP3A inhibitors or inducers can alter exposure; avoid grapefruit. Premenopausal patients may also need ovarian suppression as part of endocrine therapy.