Olaparib 150mg Tablets$185.00
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$185.00 each
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Olaparib 150mg Tablets
SKU GME1315Oncology Care
Product Introduction
Olaparib 150mg is a PARP-inhibitor anticancer treatment for selected ovarian, breast, pancreatic or prostate cancers. Eligibility depends on the cancer setting, prior treatment and relevant tumour or inherited biomarkers.
How to use
Swallow tablets whole with water, with or without food. Do not crush, dissolve or split. Avoid grapefruit and Seville oranges. Skip a missed dose and resume the next scheduled dose.
How it works
Olaparib inhibits PARP-mediated DNA repair and traps PARP on DNA. Cancer cells with deficient homologous-recombination repair are especially vulnerable.
Side effects
Nausea, fatigue, anaemia, vomiting, reduced appetite and diarrhoea can occur. Persistent low blood counts, new cough or breathlessness needs assessment.
Important information
Blood counts are checked before and during treatment. Strong or moderate CYP3A inhibitors can increase exposure. Rare marrow disorders and pneumonitis are important. Effective contraception is required because of fetal risk.
Uses
- Selected biomarker-defined ovarian, breast, pancreatic and prostate cancer treatment or maintenance settings.
Benefits
In eligible patients, PARP inhibition can delay progression or recurrence and extend disease control after an appropriate treatment response.
Why might BRCA or other tumour testing be needed?
DNA-repair markers help identify cancer settings in which benefit is established. A cancer diagnosis alone does not determine eligibility.
Are tablets interchangeable with older olaparib capsules?
No. The formulations differ in exposure and are not substituted milligram for milligram.
Can I take St John’s wort?
It can reduce olaparib exposure by inducing metabolism and should be avoided.
Does persistent tiredness always come from the cancer?
Anaemia is common during treatment. A blood count can help distinguish a treatment effect from other causes.
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