Mitotane 500mg Tablets$540.00
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$540.00 each
10–24 boxes
8% off
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Mitotane 500mg Tablets
SKU GME1452Oncology Care
Product Introduction
Mitotane 500mg is an adrenal-cortex-directed medicine used in advanced adrenocortical carcinoma. It is used when cancer cannot be adequately controlled by surgery or as part of selected continuing cancer-treatment plans.
How to use
Take the divided oral doses consistently with food; a fat-containing meal improves absorption. The dose is gradually adjusted using blood concentrations and tolerance rather than increased simply to reach a fixed tablet count.
How it works
Mitotane has a cytotoxic effect on adrenal cortical tissue and reduces adrenal steroid production. Its full anticancer mechanism is not completely understood.
Side effects
Nausea, diarrhoea, reduced appetite, dizziness and drowsiness can occur. Adrenal insufficiency, neurological toxicity and liver abnormalities are important risks.
Important information
Corticosteroid replacement is often required. Carry information about adrenal-insufficiency treatment because acute illness, injury or surgery may require additional steroid support.
Uses
- Advanced adrenocortical carcinoma and selected postoperative treatment settings.
Benefits
Can control adrenal-cancer activity and reduce excess adrenal-hormone production in responding disease.
Why are mitotane blood levels measured?
Absorption and clearance vary widely. Concentration monitoring helps balance anticancer exposure against neurological and other toxicity.
Can the medicine remain in the body after it stops?
Yes. It is stored in fatty tissue and can persist for a long time, so interactions and monitoring can remain relevant.
Why can replacement steroids still be needed?
The treatment can reduce normal adrenal-hormone production as well as affecting the tumour.
What should happen during vomiting or a serious infection?
Urgent assessment is needed because oral steroid absorption or stress-hormone requirements may change, creating adrenal-crisis risk.
Adrenocortical carcinoma: cancer of the adrenal cortex. Adrenal insufficiency: inadequate adrenal steroid production. Therapeutic drug monitoring: measurement of blood drug concentrations.; AR: Mitotane 500mg أقراص; FR: Mitotane 500mg comprimés; PT: Mitotane 500mg comprimidos; ES: Mitotane 500mg comprimidos; RU: Mitotane 500mg таблетки; ID: Mitotane 500mg tablet; VI: Mitotane 500mg viên nén; MS: Mitotane 500mg tablet; TL: Mitotane 500mg mga tableta; ZH-SG: Mitotane 500mg 片剂