Mercaptopurine 50mg Tablets$62.00
1–9 boxes
$62.00 each
10–24 boxes
8% off
25+ boxes
10% off
Mercaptopurine 50mg Tablets
SKU GME1447Oncology Care
Product Introduction
Mercaptopurine 50mg is an oral thiopurine chemotherapy used mainly in maintenance treatment for acute lymphoblastic leukaemia. It is one component of a planned multi-drug blood-cancer regimen.
How to use
Take the scheduled oral dose consistently in relation to food, at the same time each day. Avoid taking it with milk or dairy products. Do not double a missed dose. Tablet splitting requires appropriate cytotoxic handling.
How it works
Mercaptopurine is converted into thioguanine nucleotides that disrupt purine production and become incorporated into nucleic acids, suppressing abnormal cell growth.
Side effects
Low blood counts, nausea, reduced appetite and liver-test abnormalities can occur. Severe infection, liver injury and pancreatitis are important risks.
Important information
TPMT and NUDT15 activity influence sensitivity. Allopurinol requires a substantial mercaptopurine dose reduction; febuxostat can cause a dangerous interaction.
Uses
- Maintenance therapy for acute lymphoblastic leukaemia and selected other thiopurine regimens.
Benefits
Helps suppress residual leukaemia cells and maintain remission during continuing therapy.
Why might genetic testing change the starting dose?
Reduced TPMT or NUDT15 activity can cause excessive active-metabolite exposure and profound marrow suppression.
Why does allopurinol matter?
It changes mercaptopurine metabolism and can greatly increase toxicity unless the regimen is deliberately adjusted.
Why can counts fall even on a small tablet dose?
Sensitivity varies substantially between people, so blood-test response matters more than tablet size alone.
Can the tablet be taken with a glass of milk?
Milk can reduce availability. Use water and keep dairy intake separate from the dose.
Thiopurine: a medicine class affecting purine metabolism. TPMT: an enzyme involved in thiopurine breakdown. NUDT15: an enzyme affecting sensitivity to thiopurines. Maintenance: continuing therapy intended to sustain remission.; AR: Mercaptopurine 50mg أقراص; FR: Mercaptopurine 50mg comprimés; PT: Mercaptopurine 50mg comprimidos; ES: Mercaptopurine 50mg comprimidos; RU: Mercaptopurine 50mg таблетки; ID: Mercaptopurine 50mg tablet; VI: Mercaptopurine 50mg viên nén; MS: Mercaptopurine 50mg tablet; TL: Mercaptopurine 50mg mga tableta; ZH-SG: Mercaptopurine 50mg 片剂