Levothyroxine 114mcg + Liothyronine 27mcg Tablets

Product Introduction

Levothyroxine 114mcg + Liothyronine 27mcg is a thyroid-hormone replacement combining T4 and active T3 for hypothyroidism. It provides both hormones in a fixed ratio when a combined replacement regimen has been chosen.

How to use

Take with water at the same daily time on an empty stomach, 30–60 minutes before breakfast. Separate calcium, iron and thyroid-hormone-binding medicines by at least four hours. The amount of each hormone changes when the tablet strength changes, so a switch alters both the T4 and T3 doses.

How it works

Levothyroxine supplies T4, part of which is converted to T3 in body tissues. Liothyronine supplies active T3 directly. Together they restore thyroid-receptor signalling involved in metabolism and normal organ function.

Side effects

Excess replacement can cause palpitations, tremor, sweating, heat intolerance, diarrhoea, sleep disturbance or muscle weakness. T3 can produce more noticeable changes after a dose. Chest pain, fainting or a persistent irregular heartbeat needs urgent attention.

Important information

Tell your doctor about heart disease, arrhythmia, adrenal insufficiency, diabetes, osteoporosis and warfarin use. Untreated adrenal insufficiency must be corrected before thyroid replacement. T3-containing treatment requires attention to post-dose hormone changes as well as longer-term thyroid results; excess replacement can affect the heart and bones.