Leucovorin Calcium 50mg/5mL Injection$40.00
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Leucovorin Calcium 50mg/5mL Injection
SKU GME1437Oncology Care
Product Introduction
Leucovorin Calcium 50mg/5mL is an injectable reduced folate used for methotrexate rescue and selected folate-deficiency situations. It is also combined with fluorouracil in certain cancer regimens, where it enhances the chemotherapy effect.
How to use
It is given intravenously or intramuscularly according to the regimen and must never be injected into the spinal canal. Methotrexate-rescue doses are timed from the methotrexate treatment and adjusted using drug levels and kidney function.
How it works
Leucovorin supplies reduced folate without requiring the enzyme blocked by methotrexate. With fluorouracil it stabilises the inhibitory complex at thymidylate synthase.
Side effects
Allergic reactions are uncommon. With fluorouracil, severe diarrhoea, mouth ulcers and other fluorouracil-related toxicities can be intensified.
Important information
Leucovorin is not a substitute for vitamin B12 treatment in pernicious anaemia. Delayed methotrexate clearance needs coordinated rescue, hydration and monitoring rather than a single unplanned injection.
Uses
- Methotrexate rescue, selected folate-deficiency treatment and enhancement of fluorouracil-based regimens.
Benefits
Protects healthy cells after methotrexate exposure or strengthens fluorouracil activity, depending on the regimen.
Is leucovorin always a chemotherapy antidote?
No. It provides rescue with methotrexate, but enhances fluorouracil’s anticancer effect in other regimens.
Why is rescue timing important?
Starting too late can reduce protection from methotrexate toxicity; timing is part of the complete methotrexate protocol.
Does it remove methotrexate from the blood?
No. It helps cells bypass folate blockade; clearance still depends on kidney function and other measures.
Can ordinary folic acid replace it during high-dose methotrexate rescue?
No. Folic acid does not provide the same immediate reduced-folate bypass.
Folinic acid: another name for leucovorin. Rescue therapy: treatment limiting toxicity from another medicine. Thymidylate synthase: an enzyme needed for DNA production.; AR: Leucovorin Calcium 50mg/5mL حقن; FR: Leucovorin Calcium 50mg/5mL injection; PT: Leucovorin Calcium 50mg/5mL injeção; ES: Leucovorin Calcium 50mg/5mL inyección; RU: Leucovorin Calcium 50mg/5mL инъекция; ID: Leucovorin Calcium 50mg/5mL suntikan; VI: Leucovorin Calcium 50mg/5mL thuốc tiêm; MS: Leucovorin Calcium 50mg/5mL suntikan; TL: Leucovorin Calcium 50mg/5mL iniksyon; ZH-SG: Leucovorin Calcium 50mg/5mL 注射剂