L-Asparaginase 5000iu Injection$37.00
1–9 boxes
$37.00 each
10–24 boxes
8% off
25+ boxes
10% off
L-Asparaginase 5000iu Injection
SKU GME1432Oncology Care
Product Introduction
L-Asparaginase 5000iu is an enzyme chemotherapy used in acute lymphoblastic leukaemia as part of a multi-drug regimen. This is native L-asparaginase rather than a pegylated long-acting formulation.
How to use
After reconstitution, native L-asparaginase is administered by intravenous infusion or intramuscular injection within a planned leukaemia regimen, with observation for allergic reactions. Native and pegylated preparations use different schedules and are not interchanged by vial count.
How it works
L-asparaginase breaks down circulating asparagine. Leukaemia cells that cannot make enough of this amino acid lose an essential supply needed for protein production.
Side effects
Allergic reactions, nausea, abdominal pain and raised liver enzymes can occur. Pancreatitis, high blood glucose, blood clots and bleeding are important risks.
Important information
Liver function, glucose, pancreatic enzymes and clotting proteins may be monitored. A previous asparaginase reaction affects the choice of enzyme preparation.
Uses
- Acute lymphoblastic leukaemia combination chemotherapy.
Benefits
Adds an enzyme-based action against leukaemia cells that complements other medicines in the regimen.
Why can both clotting and bleeding occur?
Asparaginase can reduce production of several clotting and anti-clotting proteins, disturbing the balance in either direction.
Can it stop working without an obvious allergic reaction?
Yes. Antibodies can inactivate the enzyme without visible allergy, called silent inactivation; enzyme-activity testing may detect this.
Why is severe upper-abdominal pain important?
It can indicate pancreatitis, particularly when accompanied by vomiting, and needs urgent assessment.
Is a pegylated asparaginase vial equivalent?
No. Pegylation changes how long the enzyme remains active and therefore changes the dosing schedule.
Asparagine: an amino acid used to build proteins. Silent inactivation: loss of enzyme activity without overt allergy. Pancreatitis: inflammation of the pancreas.; AR: L-Asparaginase 5000iu حقن; FR: L-Asparaginase 5000iu injection; PT: L-Asparaginase 5000iu injeção; ES: L-Asparaginase 5000iu inyección; RU: L-Asparaginase 5000iu инъекция; ID: L-Asparaginase 5000iu suntikan; VI: L-Asparaginase 5000iu thuốc tiêm; MS: L-Asparaginase 5000iu suntikan; TL: L-Asparaginase 5000iu iniksyon; ZH-SG: L-Asparaginase 5000iu 注射剂