L-Asparaginase 10000IU Injection$32.00
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L-Asparaginase 10000IU Injection
SKU GME1126Oncology Care
Product Introduction
L-Asparaginase 10000IU is an enzyme-based anticancer treatment used in multi-medicine regimens for acute lymphoblastic leukaemia. It deprives susceptible leukaemia cells of an amino acid they depend on for survival.
How to use
A chemotherapy professional reconstitutes the powder and administers it by the injection route used in the non-pegylated asparaginase protocol. Dose, interval and observation are arranged around the leukaemia regimen, with emergency treatment available for allergy. It is not interchangeable dose-for-dose with pegaspargase or other asparaginase preparations.
How it works
L-asparaginase breaks down circulating asparagine into aspartic acid and ammonia. Leukaemia cells with limited ability to make their own asparagine lose an essential supply needed for protein synthesis.
Side effects
Nausea, fever, reduced appetite, liver-test changes and high blood glucose can occur. Serious risks include allergy, pancreatitis, liver injury, blood clots and bleeding. Severe abdominal pain, a swollen painful limb or sudden neurological symptoms needs urgent treatment.
Important information
Monitoring includes glucose, liver function, clotting factors and pancreatic symptoms; enzyme-activity testing may detect inadequate exposure. Previous asparaginase allergy, pancreatitis or significant clotting complications affects subsequent treatment. Different bacterial-source and pegylated formulations have different dosing schedules.
Uses
- Acute lymphoblastic leukaemia as part of an appropriate multi-agent chemotherapy protocol using non-pegylated L-asparaginase.
Benefits
Amino-acid depletion adds a mechanism distinct from DNA-damaging chemotherapy and helps eradicate susceptible leukaemia cells. Maintaining adequate enzyme exposure contributes to the effectiveness of the overall leukaemia regimen.
Is L-asparaginase the same as pegaspargase?
No. Pegaspargase has a polyethylene-glycol modification that changes its persistence and schedule. Equal numerical units do not establish an interchangeable dose or interval.
Can this treatment cause both clots and bleeding?
Yes. Changes in liver production of clotting and anticoagulant proteins can disturb the balance in either direction. Both unusual bleeding and symptoms of a clot need attention.
What is silent inactivation?
Antibodies can neutralise an asparaginase product without an obvious allergic reaction. Measuring enzyme activity can identify inadequate treatment exposure despite apparently normal administration.
Why is severe upper-abdominal pain important?
It can be a sign of pancreatitis, particularly with vomiting or pain radiating to the back. This is different from mild nausea and requires urgent assessment.
Asparagine: amino acid needed for protein synthesis. ALL: acute lymphoblastic leukaemia. Enzyme activity: measure of a biological enzyme's function. Silent inactivation: antibody-related loss of enzyme activity without obvious allergy. Non-pegylated: not modified with polyethylene glycol.; AR: L-Asparaginase 10000IU حقن; FR: L-Asparaginase 10000IU préparation injectable; PT: L-Asparaginase 10000IU injetável; ES: L-Asparaginase 10000IU inyectable; RU: L-Asparaginase 10000IU инъекционная форма; ID: L-Asparaginase 10000IU injeksi; VI: L-Asparaginase 10000IU thuốc tiêm; MS: L-Asparaginase 10000IU suntikan; TL: L-Asparaginase 10000IU iniksyon; ZH-SG: L-Asparaginase 10000IU 注射剂