Itraconazole 400mg SR Tablets$114.00
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Itraconazole 400mg SR Tablets
SKU GME623Product Introduction
Itraconazole 400mg is a sustained-release oral triazole antifungal for selected susceptible fungal infections. Its release design and exposure must be considered separately from conventional itraconazole capsules.
How to use
Take the sustained-release tablet with or just after food. Swallow it whole without crushing, splitting or chewing. Do not replace it with a different itraconazole formulation by matching the total milligrams alone.
How it works
Inhibition of fungal lanosterol 14-alpha-demethylase reduces ergosterol synthesis, disrupting the fungal cell membrane.
Side effects
Nausea, abdominal pain, diarrhoea, headache and abnormal liver tests can occur.
Important information
Tell your doctor about heart failure, liver disease and every medicine you take. Itraconazole can worsen heart pumping function and has major CYP3A4 interactions.
Uses
- Susceptible fungal skin, nail or systemic infections as appropriate to the formulation
Benefits
Treats the fungal cause rather than merely suppressing itching or inflammation.
Can this 400mg formulation be exchanged for conventional itraconazole capsules?
Not by matching milligrams alone. Release design and absorption differ, so changing formulation requires a new treatment plan rather than a tablet-for-capsule substitution.
Does every itraconazole formulation respond to acid-reducing medicines in the same way?
No. Conventional capsules and enhanced-bioavailability preparations can differ in their response to gastric acidity. Tell the prescriber about proton-pump inhibitors, H2 blockers and antacids rather than transferring instructions from a different formulation.
Can I take a statin without telling the prescriber?
Some statins, particularly simvastatin and lovastatin, have contraindicated interactions with itraconazole.
Which symptoms could indicate heart failure?
New breathlessness, ankle swelling or rapid weight gain needs prompt review.
Which liver symptoms should I report?
Dark urine, yellow eyes, persistent nausea or loss of appetite requires assessment.
Can a nail look abnormal after the fungus is treated?
Yes. Normal nail appearance depends on healthy nail growing out and may take months.
Can topical cream replace treatment for a systemic infection?
No. Local and systemic formulations have different indications.
Why should recurring ringworm be reassessed?
Diagnosis, resistance, adherence and reinfection can all affect response; repeating courses without review may miss the cause.
Ergosterol: a component of fungal cell membranes. CYP3A4: an enzyme involved in many drug interactions. Bioavailability: the fraction of a dose reaching the circulation., AR: Itraconazole أقراص ممتدة التحرر, FR: Itraconazole comprimés à libération prolongée, PT: Itraconazole comprimidos de libertação prolongada, ES: Itraconazole comprimidos de liberación prolongada, RU: Itraconazole таблетки пролонгированного действия, ID: Itraconazole lepas lambat, VI: Itraconazole viên nén giải phóng kéo dài, MS: Itraconazole pelepasan berpanjangan, TL: Itraconazole tabletang may pinahabang paglabas, ZH-SG: Itraconazole 缓释片