Aminophylline 250mg/10mL

Product Introduction

Aminophylline 250mg/10mL is an injectable bronchodilator containing aminophylline, a theophylline-ethylenediamine complex. It relaxes airway smooth muscle and can improve airflow, but it has a narrow safety margin, meaning the helpful and toxic blood levels can be close. For that reason, aminophylline injection is not a first-choice rescue inhaler and should not be used casually for sudden breathlessness at home.

How to use

Aminophylline 250mg/10mL is given by a doctor or nurse as a slow IV injection or drip. It should not be self-administered. The infusion rate and dose may be adjusted using symptoms, heart rate, side effects, potassium, and theophylline blood levels. A fast-acting rescue inhaler or nebulized bronchodilator may still be needed for sudden symptoms.

How it works

Aminophylline releases theophylline, a methylxanthine bronchodilator. It relaxes airway smooth muscle and may improve diaphragmatic contractility, helping airflow in reversible airway obstruction.

Common side effects

Possible side effects include nausea, vomiting, diarrhoea, restlessness, irritability, tremor, headache, insomnia, palpitations, increased urination, and low potassium. Toxicity can cause severe vomiting, fast or irregular heartbeat, seizures, severe agitation, low blood pressure, or dangerous arrhythmias.

Important information

Use caution in heart disease, liver disease, kidney disease, seizures, hyperthyroidism, fever, older age, pregnancy, breastfeeding, and smoking changes. Important interactions include beta-blockers, fluoroquinolone antibiotics, macrolides, cimetidine, anticonvulsants, and other theophylline products. Do not mix in a syringe with other medicines unless compatibility is confirmed.