Fluorouracil 250mg/5mL (50mg/mL) Injection$40.00
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Fluorouracil 250mg/5mL (50mg/mL) Injection
SKU GME1412Oncology Care
Product Introduction
Fluorouracil 250mg/5mL (50mg/mL) is injectable fluoropyrimidine chemotherapy used in colorectal, gastric, pancreatic, breast and selected other cancer regimens. It is supplied for intravenous treatment, not for topical skin application.
How to use
The prepared medicine is given into a vein as an injection or controlled infusion according to the regimen. A pump may deliver a longer infusion. DPD deficiency is assessed before treatment where testing is available.
How it works
Fluorouracil interferes with thymidylate synthesis and becomes incorporated into RNA and DNA, disrupting the growth of rapidly dividing cells.
Side effects
Mouth ulcers, diarrhoea, low blood counts, nausea and hand-foot skin reactions can occur. Severe early toxicity and heart-related chest pain are important risks.
Important information
Tell the team about previous severe fluoropyrimidine reactions and heart disease. Brivudine can cause a dangerous interaction and requires a sufficient treatment-free interval.
Uses
- Colorectal, gastric, pancreatic, breast and selected other fluoropyrimidine-sensitive cancers.
Benefits
Can reduce tumour-cell growth and support disease control, often as part of combination chemotherapy.
What is DPD deficiency?
It is reduced activity of an enzyme that breaks down fluorouracil. Deficiency can greatly increase exposure and cause unusually severe toxicity.
Why is severe diarrhoea early in the course important?
Early, rapidly worsening diarrhoea or mouth ulcers can signal excessive exposure and needs urgent assessment before further medicine is delivered.
Why is leucovorin sometimes given with it?
Leucovorin strengthens fluorouracil’s inhibition of thymidylate synthase. In this combination it enhances the anticancer effect rather than acting as a rescue medicine.
What should I do if an infusion pump leaks or stops?
Contact the chemotherapy service promptly. Do not reconnect a leaking line or change the pump rate yourself.
Fluoropyrimidine: a chemotherapy class that interferes with nucleic-acid production. DPD: the enzyme that breaks down fluorouracil. Hand-foot syndrome: soreness and redness of palms and soles.; AR: Fluorouracil 250mg/5mL (50mg/mL) حقن; FR: Fluorouracil 250mg/5mL (50mg/mL) injection; PT: Fluorouracil 250mg/5mL (50mg/mL) injeção; ES: Fluorouracil 250mg/5mL (50mg/mL) inyección; RU: Fluorouracil 250mg/5mL (50mg/mL) инъекция; ID: Fluorouracil 250mg/5mL (50mg/mL) suntikan; VI: Fluorouracil 250mg/5mL (50mg/mL) thuốc tiêm; MS: Fluorouracil 250mg/5mL (50mg/mL) suntikan; TL: Fluorouracil 250mg/5mL (50mg/mL) iniksyon; ZH-SG: Fluorouracil 250mg/5mL (50mg/mL) 注射剂