Cyclophosphamide 1g Injection

Cyclophosphamide 1g is an injectable alkylating medicine used in treatment combinations for lymphoma, leukaemia, breast cancer and certain other cancers. It is also used in some treatment protocols for severe immune-mediated disease.
The reconstituted medicine is administered intravenously on the planned treatment days. Hydration, regular bladder emptying and, for relevant higher-dose regimens, mesna reduce urinary-tract toxicity. Antiemetic treatment is planned before administration.
Liver enzymes activate cyclophosphamide to metabolites that cross-link DNA, suppressing susceptible malignant and immune cells.
Low blood counts, nausea, vomiting, hair loss and infection can occur. Haemorrhagic cystitis, infertility and dose-related cardiac or lung toxicity are serious concerns.
Blood counts, kidney function and urine symptoms require monitoring. Fertility preservation can be relevant before treatment. High-dose exposure requires additional organ monitoring.
Can reduce cancer-cell burden or suppress excessive immune activity, helping bring the treated disease under control.
Mesna binds the urinary toxic metabolite acrolein and reduces bladder injury in regimens where that protection is needed.
No. Hydration is individualised for the dose, kidney function and cardiac status.
Yes. Ovarian or testicular injury can be lasting, so preservation options may need discussion before treatment.
Report blood in the urine or painful urination promptly, even after the infusion has finished. These can be signs of haemorrhagic cystitis and need assessment before further treatment; drinking extra water alone is not a sufficient response.
Acrolein: a metabolite that can irritate the bladder. Mesna: a urinary-tract protective medicine. Haemorrhagic cystitis: bladder inflammation with bleeding.; AR: Cyclophosphamide 1g حقن; FR: Cyclophosphamide 1g injection; PT: Cyclophosphamide 1g injeção; ES: Cyclophosphamide 1g inyección; RU: Cyclophosphamide 1g инъекция; ID: Cyclophosphamide 1g suntikan; VI: Cyclophosphamide 1g thuốc tiêm; MS: Cyclophosphamide 1g suntikan; TL: Cyclophosphamide 1g iniksyon; ZH-SG: Cyclophosphamide 1g 注射剂
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Cyclophosphamide 1g Injection