Carfilzomib 60mg Injection$185.00
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Carfilzomib 60mg Injection
SKU GME1341Oncology Care
Product Introduction
Carfilzomib 60mg is an injectable proteasome inhibitor used in selected multiple-myeloma regimens, commonly with other anticancer medicines.
How to use
The reconstituted medicine is administered by intravenous infusion. Hydration is planned around the regimen, with fluid intake adjusted for cardiac or kidney status.
How it works
Carfilzomib irreversibly inhibits the proteasome, causing accumulation of abnormal proteins and death of susceptible myeloma cells.
Side effects
Fatigue, anaemia, low platelets, nausea, fever and breathlessness can occur. Heart failure, hypertension, kidney injury and infusion reactions are important serious effects.
Important information
Blood pressure, renal function, blood counts and signs of cardiac stress require monitoring. Both dehydration and excessive fluid loading can be harmful. Thrombosis prevention depends on the combination regimen.
Uses
- Selected relapsed or refractory multiple-myeloma treatment regimens.
Benefits
Proteasome inhibition can reduce malignant plasma-cell burden and deepen response to combination therapy.
Is it injected under the skin like some bortezomib regimens?
No. Carfilzomib is administered intravenously.
Why is hydration individualised?
Adequate hydration supports renal safety, but excess fluid can worsen heart failure or breathlessness.
What should I report after an infusion?
New breathlessness, chest pain, marked swelling, reduced urine output or fever requires prompt assessment.
Why is dexamethasone given before carfilzomib?
Dexamethasone premedication reduces the likelihood and severity of infusion reactions, particularly early in treatment. Reactions can begin during the infusion or up to 24 hours later, so new symptoms after leaving the clinic still matter.
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