Carboplatin 450mg/45mL (10mg/mL) Injection$40.00
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Carboplatin 450mg/45mL (10mg/mL) Injection
SKU GME1372Oncology Care
Product Introduction
Carboplatin 450mg/45mL (10mg/mL) is a platinum chemotherapy used in selected ovarian, lung and other cancer regimens.
How to use
The clinical team administers a prepared intravenous infusion, usually over at least 15 minutes. Kidney function and target drug exposure commonly determine the dose through the Calvert formula. Compatible equipment without aluminium is used.
How it works
Carboplatin forms platinum–DNA cross-links that interfere with DNA replication and trigger death of susceptible cancer cells.
Side effects
Low platelets, neutropenia, anaemia, nausea, vomiting and fatigue can occur. Hypersensitivity, kidney injury and hearing changes are important additional concerns.
Important information
Blood counts and renal function guide each cycle. Prior platinum exposure increases concern about hypersensitivity. Other nephrotoxic or ototoxic medicines can increase adverse effects.
Uses
- Selected ovarian, lung and other cancers within an appropriate platinum-based regimen.
Benefits
Platinum-induced DNA damage can shrink or control a susceptible tumour as part of chemotherapy.
Why is the dose linked to kidney function?
Carboplatin clearance closely follows renal filtration, so reduced kidney function increases exposure and marrow toxicity.
Why is there a break between carboplatin treatment cycles?
Blood-cell counts can stay low for several weeks after treatment. The break allows the bone marrow to recover. A later cycle may be delayed if blood counts or kidney function have not recovered enough.
Can an allergy develop after earlier uneventful cycles?
Yes. Hypersensitivity is more likely after repeated platinum exposure and may occur despite previous tolerance.
Is it interchangeable with cisplatin?
No. Their dosing, toxicity and indications differ, so a substitution requires a new regimen.
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