Busulfan 60mg/10mL (6mg/mL) Injection$84.00
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Busulfan 60mg/10mL (6mg/mL) Injection
SKU GME1367Oncology Care
Product Introduction
Busulfan 60mg/10mL (6mg/mL) is an intravenous alkylating medicine used in conditioning regimens before haematopoietic stem-cell transplantation. Its transplant role differs from older low-dose oral busulfan treatment.
How to use
The concentrate is diluted and delivered by a controlled intravenous infusion, commonly over 2 hours in a divided-dose conditioning regimen. Anticonvulsant prophylaxis and antiemetic treatment are provided. Drug-exposure sampling may guide later doses. Other conditioning schedules use their own infusion plan.
How it works
Busulfan cross-links DNA and suppresses marrow cells, helping prepare the body for the planned stem-cell graft.
Side effects
Profound marrow suppression, nausea, mouth inflammation, infection and liver toxicity can occur. Seizures, lung toxicity and hepatic sinusoidal obstruction syndrome are important serious risks.
Important information
Dose calculations and exposure monitoring account for weight, age and the regimen. Metronidazole and some antifungals can increase exposure.
Uses
- Conditioning before haematopoietic stem-cell transplantation as part of a defined combination regimen.
Benefits
Controlled marrow ablation and immune suppression help create conditions for engraftment of the transplanted cells.
Why does the transplant team ask about paracetamol before busulfan?
Paracetamol can affect glutathione, a substance involved in clearing busulfan, and may increase busulfan exposure. Tell the transplant team when you last took it before using it for fever or pain during conditioning.
Why is seizure prevention given without a seizure history?
Busulfan can provoke seizures at conditioning exposure, so prophylaxis is planned before treatment.
What does AUC monitoring measure?
It estimates total drug exposure over time, helping avoid both insufficient conditioning and excessive toxicity.
Why is rapid weight gain with abdominal swelling important?
It can signal hepatic sinusoidal obstruction and fluid retention during transplant conditioning and needs urgent assessment.
Conditioning: treatment preparing for a stem-cell transplant. AUC: total drug exposure over time. Engraftment: establishment of transplanted blood-forming cells.; AR: Busulfan 60mg/10mL (6mg/mL) حقن; FR: Busulfan 60mg/10mL (6mg/mL) injection; PT: Busulfan 60mg/10mL (6mg/mL) injeção; ES: Busulfan 60mg/10mL (6mg/mL) inyección; RU: Busulfan 60mg/10mL (6mg/mL) инъекция; ID: Busulfan 60mg/10mL (6mg/mL) suntikan; VI: Busulfan 60mg/10mL (6mg/mL) thuốc tiêm; MS: Busulfan 60mg/10mL (6mg/mL) suntikan; TL: Busulfan 60mg/10mL (6mg/mL) iniksyon; ZH-SG: Busulfan 60mg/10mL (6mg/mL) 注射剂