Arsenic Trioxide 10mg/10mL (1mg/mL) Injection$51.00
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Arsenic Trioxide 10mg/10mL (1mg/mL) Injection
SKU GME1346Oncology Care
Product Introduction
Arsenic Trioxide 10mg/10mL (1mg/mL) is a differentiating anticancer medicine for acute promyelocytic leukaemia, used alone or with all-trans retinoic acid according to the risk and treatment setting.
How to use
The concentrate is diluted and given by intravenous infusion in a monitored oncology setting. ECG, electrolytes and clinical observations guide treatment. It is not an intravenous bolus.
How it works
Arsenic trioxide promotes degradation of the PML–RARα fusion protein and encourages differentiation and death of abnormal promyelocytes.
Side effects
Nausea, fatigue, oedema, increased glucose and liver-enzyme changes may occur. Differentiation syndrome and QT prolongation are potentially life-threatening.
Important information
Potassium and magnesium are corrected and monitored. Fever, weight gain, swelling or breathlessness may indicate differentiation syndrome and requires urgent treatment. QT-prolonging medicines increase arrhythmia risk.
Uses
- Acute promyelocytic leukaemia in an appropriate induction or consolidation regimen.
Benefits
Promoting maturation and removal of abnormal promyelocytes can produce remission in a molecularly defined leukaemia.
Is it used for every form of leukaemia?
No. Its established role is specific to APL, generally involving the PML–RARα abnormality.
What is differentiation syndrome?
It is an inflammatory complication that can cause fever, fluid retention, low blood pressure and breathing difficulty. It needs immediate treatment.
Why are ECGs repeated?
QT prolongation can lead to dangerous rhythm disturbances, particularly with low potassium or magnesium.
Can arsenic trioxide cause numbness or tingling in the hands and feet?
Peripheral nerve effects can occur. Report new or worsening numbness, tingling or limb weakness promptly, particularly if it affects walking, balance or using your hands.
APL: acute promyelocytic leukaemia. Differentiation: maturation of cells. QT prolongation: delayed cardiac electrical recovery.; AR: Arsenic Trioxide 10mg/10mL (1mg/mL) حقن; FR: Arsenic Trioxide 10mg/10mL (1mg/mL) injection; PT: Arsenic Trioxide 10mg/10mL (1mg/mL) injeção; ES: Arsenic Trioxide 10mg/10mL (1mg/mL) inyección; RU: Arsenic Trioxide 10mg/10mL (1mg/mL) инъекция; ID: Arsenic Trioxide 10mg/10mL (1mg/mL) suntikan; VI: Arsenic Trioxide 10mg/10mL (1mg/mL) thuốc tiêm; MS: Arsenic Trioxide 10mg/10mL (1mg/mL) suntikan; TL: Arsenic Trioxide 10mg/10mL (1mg/mL) iniksyon; ZH-SG: Arsenic Trioxide 10mg/10mL (1mg/mL) 注射剂