Acetazolamide 250mg Tablets

Product Introduction

Acetazolamide 250mg is a carbonic-anhydrase inhibitor used to lower raised eye pressure in glaucoma and in selected regimens for altitude illness, fluid retention or certain seizure disorders. The intended condition determines the dose and length of treatment.

How to use

Take the tablet with water, with food if it causes nausea. When divided doses are used, an earlier final dose can reduce night-time urination. Altitude-prevention regimens begin before ascent; developing severe altitude symptoms still requires stopping ascent and arranging descent.

How it works

Acetazolamide inhibits carbonic anhydrase. It reduces aqueous-humour production in the eye and increases bicarbonate loss through the kidneys. The resulting change in acid-base balance also stimulates ventilation at altitude.

Side effects

Tingling in fingers or toes, increased urination, altered taste, nausea and tiredness are common. Severe rash, unusual bruising, marked weakness, confusion or rapid breathing can indicate a serious reaction or electrolyte disturbance.

Important information

Avoid use with severe kidney or liver disease, low sodium or potassium, or existing hyperchloraemic acidosis. Blood electrolytes and kidney function may need monitoring. High-dose aspirin can cause a serious interaction. Kidney-stone history and pregnancy are important before treatment.