Abemaciclib 150mg Tablets$269.00
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Abemaciclib 150mg Tablets
SKU GME1491Oncology Care
Product Introduction
Abemaciclib 150mg is a CDK4/6 inhibitor for selected hormone-receptor-positive, HER2-negative breast cancers. It may be combined with endocrine treatment in early high-risk or advanced disease, or used alone in an appropriate previously treated setting.
How to use
Swallow the tablet whole with water at the scheduled morning and evening times, with or without food. Do not split, crush or chew. Avoid grapefruit.
How it works
Abemaciclib inhibits cyclin-dependent kinases 4 and 6, interrupting the cell-cycle signals that allow hormone-responsive breast-cancer cells to divide.
Side effects
Diarrhoea, nausea, fatigue, low white-cell counts, anaemia and reduced appetite can occur. Blood clots, liver injury and interstitial lung disease are important serious risks.
Important information
Start the supplied anti-diarrhoeal treatment at the first loose stool and replace fluids. Blood counts and liver tests are monitored. Report unilateral leg swelling, chest pain, fever or new breathlessness promptly.
Uses
- Selected HR-positive, HER2-negative early high-risk or advanced breast cancer.
Benefits
Adding cell-cycle inhibition to a suitable endocrine regimen can reduce recurrence risk or delay progression, depending on the disease setting.
Is abemaciclib the same as an aromatase inhibitor?
No. It blocks cell-cycle kinases, while an aromatase inhibitor reduces oestrogen production. Their complementary actions explain why they may be combined.
Why is early diarrhoea management important?
Diarrhoea often starts in the first week and can lead to dehydration. Persistent or severe symptoms may require a treatment interruption or dose reduction.
What if I miss or vomit an abemaciclib dose?
Skip that dose and take the next one at its usual scheduled time. Do not take another tablet after vomiting or double a later dose to catch up.
Can creatinine rise without a true fall in kidney filtration?
Abemaciclib can reduce tubular creatinine secretion. Other kidney-function measures may help distinguish this effect from kidney injury.
CDK4/6: enzymes that regulate cell-cycle progression. HR-positive: cancer expressing hormone receptors. Endocrine therapy: treatment that reduces hormone stimulation of a tumour.; AR: Abemaciclib 150mg أقراص; FR: Abemaciclib 150mg comprimés; PT: Abemaciclib 150mg comprimidos; ES: Abemaciclib 150mg comprimidos; RU: Abemaciclib 150mg таблетки; ID: Abemaciclib 150mg tablet; VI: Abemaciclib 150mg viên nén; MS: Abemaciclib 150mg tablet; TL: Abemaciclib 150mg mga tableta; ZH-SG: Abemaciclib 150mg 片剂