Rivaroxaban 2.5mg Tablets

Product Introduction

Rivaroxaban 2.5mg is the low-dose vascular presentation of a factor-Xa inhibitor used with low-dose aspirin in selected adults with coronary or peripheral artery disease. This regimen aims to reduce major cardiovascular or limb-related thrombotic events and is distinct from full-dose treatment for atrial fibrillation or an acute venous clot.

How to use

The vascular regimen uses one 2.5mg tablet twice daily, with or without food, together with the planned low-dose aspirin. Do not add extra aspirin or substitute this low-dose regimen for a full-dose anticoagulation schedule.

How it works

Rivaroxaban directly inhibits activated factor X, or factor Xa. This reduces thrombin generation and the formation of fibrin clots without acting as a platelet inhibitor like aspirin.

Side effects

Bruising, nosebleeds, gum bleeding and anaemia can occur. Bleeding that will not stop, black stools, blood in urine, vomiting blood, a severe headache after a fall or sudden weakness needs urgent assessment.

Important information

Active significant bleeding, severe liver disease with impaired clotting and major kidney impairment are important contraindication or dose-selection issues. Strong CYP3A4/P-glycoprotein inhibitors or inducers can alter exposure. Tell the procedural team before spinal injections, surgery or dental procedures. NSAIDs, other anticoagulants and antiplatelets can increase bleeding.