Vericiguat 2.5mg Tablets$34.00
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$34.00 each
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Vericiguat 2.5mg Tablets
SKU GME1073Product Introduction
Vericiguat 2.5mg is a soluble guanylate-cyclase stimulator used alongside other heart-failure medicines in adults with symptomatic chronic heart failure and reduced ejection fraction after a recent worsening event. It is an add-on treatment for longer-term outcomes, not immediate relief of fluid overload.
How to use
Take once daily with food. Treatment is increased gradually, usually at about two-week intervals, as blood pressure and tolerability allow. If swallowing is difficult, the tablet can be crushed and mixed with water immediately before taking it.
How it works
Vericiguat directly stimulates soluble guanylate cyclase and enhances its response to nitric oxide. This increases cyclic GMP, supporting relaxation of blood vessels and signalling relevant to heart and vascular function.
Side effects
Low blood pressure, dizziness and anaemia are important adverse effects. Fainting, severe weakness, worsening breathlessness or symptoms of significant blood loss need medical assessment.
Important information
Do not use during pregnancy because fetal harm is possible. Effective contraception is needed during treatment and for one month afterwards. Do not combine with another soluble guanylate-cyclase stimulator such as riociguat. PDE5 inhibitors such as sildenafil or tadalafil can add hypotension. Blood pressure and haemoglobin guide follow-up.
Uses
- Add-on treatment of symptomatic chronic heart failure with reduced ejection fraction after recent worsening requiring hospital care or intravenous diuretics.
Benefits
In the studied heart-failure population, it reduces the combined risk of cardiovascular death or heart-failure hospitalisation when added to established treatment. It does not replace the other components of heart-failure care.
Why is the dose increased gradually?
Gradual titration allows blood pressure and symptoms to be assessed before moving to a higher daily amount.
Can it replace a water tablet when my legs swell?
No. It is not a diuretic and does not quickly remove excess fluid. New swelling or rapid weight gain may require adjustment of the fluid-management plan.
Can I take tadalafil or sildenafil with vericiguat?
Both can increase the risk of symptomatic low blood pressure. They should not be added to this heart-failure regimen independently.
Why might haemoglobin be checked during treatment?
Anaemia can occur and may worsen tiredness or breathlessness. A haemoglobin result helps distinguish it from other causes of heart-failure symptoms.
Reduced ejection fraction: reduced proportion of blood pumped out by the left ventricle; Soluble guanylate cyclase: an enzyme generating cyclic GMP; Nitric oxide: a signalling molecule involved in blood-vessel relaxation; Titration: gradual adjustment of a dose; Anaemia: a reduced haemoglobin level or red-cell oxygen-carrying capacity; AR: Vericiguat 2.5mg أقراص; FR: Vericiguat 2.5mg comprimés; PT: Vericiguat 2.5mg comprimidos; ES: Vericiguat 2.5mg comprimidos; RU: Vericiguat 2.5mg таблетки; ID: Vericiguat 2.5mg tablet; VI: Vericiguat 2.5mg viên nén; MS: Vericiguat 2.5mg tablet; TL: Vericiguat 2.5mg tableta; ZH-SG: Vericiguat 2.5mg 片剂