Valganciclovir 450mg Tablets$28.00
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$28.00 each
10–24 boxes
8% off
25+ boxes
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Valganciclovir 450mg Tablets
SKU GME1482Antiviral
Product Introduction
Valganciclovir 450mg is an oral antiviral used to treat CMV retinitis in adults with HIV-related immune suppression and to prevent CMV disease in selected transplant recipients. It is converted in the body to ganciclovir.
How to use
Take the tablets with food and swallow them whole. Treatment and prevention use different schedules, and kidney function determines the dose. Do not crush tablets or replace a measured oral-solution dose without recalculation.
How it works
The active ganciclovir triphosphate inhibits viral DNA polymerase, reducing CMV DNA production and viral replication.
Side effects
Low neutrophils, anaemia, low platelets, diarrhoea and nausea can occur. Severe marrow suppression and kidney-related accumulation are important risks.
Important information
Blood counts and kidney function are monitored. It can harm fertility and an unborn baby; effective pregnancy prevention is required. Other marrow-suppressing or kidney-toxic medicines need particular attention.
Uses
- CMV retinitis treatment and CMV-disease prevention in selected transplant settings.
Benefits
Can control CMV replication and reduce the risk of CMV-related organ disease in eligible patients.
Is a prevention dose the same as a retinitis-treatment dose?
No. Induction, maintenance and transplant prophylaxis are distinct treatment phases with different dosing schedules.
Does it eliminate CMV from the body?
No. CMV can remain latent, so infection may recur when immune protection is reduced.
Why can a kidney-function change alter the tablet schedule?
Ganciclovir is cleared through the kidneys; impaired clearance can greatly increase blood and other toxicity.
Why are eye examinations continued during retinitis treatment?
Changes in retinal disease may need detection before a major change in vision is noticed, even while antiviral treatment continues.
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