Sulfamethoxazole 500mg + Pyrimethamine 25mg Tablets$28.00
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Sulfamethoxazole 500mg + Pyrimethamine 25mg Tablets
SKU GME1266Antiparasitic
Product Introduction
Sulfamethoxazole 500mg + Pyrimethamine 25mg is an antifolate antimalarial combination. It pairs a sulfonamide with a medicine that blocks parasite folate metabolism, helping inhibit the growth of susceptible malaria parasites.
How to use
Swallow the tablets with water after food. Maintain adequate fluid intake during treatment. The treatment schedule is specific to this combination and must not be substituted with a co-trimoxazole or sulfadoxine-pyrimethamine schedule.
How it works
Sulfamethoxazole inhibits parasite dihydropteroate synthase, while pyrimethamine inhibits dihydrofolate reductase. The sequential block reduces folate needed for parasite growth.
Side effects
Nausea, vomiting, headache and rash may occur. Blistering rash, mouth sores, sore throat with fever or unusual bruising needs urgent attention because serious skin or blood reactions can occur.
Important information
Tell your doctor about sulfonamide allergy, folate-deficiency blood disorders, kidney or liver disease, pregnancy or breastfeeding. Additional antifolate medicines can increase blood-cell toxicity, and blood counts may need monitoring during treatment.
Uses
- Treatment of susceptible malaria in a suitable antimalarial regimen.
Benefits
The complementary antifolate actions help clear susceptible parasites and control the infection responsible for malarial fever.
Can this be used for any fever?
No. Fever has many causes. Malaria testing and the likely parasite sensitivity determine whether an antimalarial regimen is appropriate.
Is this the same as co-trimoxazole?
No. Co-trimoxazole combines sulfamethoxazole with trimethoprim. This tablet pairs sulfamethoxazole with pyrimethamine, so their treatment schedules are not interchangeable.
What if a rash appears after the tablets?
Stop further doses and obtain urgent medical advice, especially with fever, mouth ulcers, eye irritation or skin blistering. Severe sulfonamide skin reactions can progress quickly.
Can I use it alone for severe malaria?
Severe illness, confusion, breathing difficulty, repeated vomiting or inability to drink needs urgent hospital treatment rather than reliance on an oral antifolate combination.
Why should I avoid adding another sulfonamide or antifolate medicine?
Combining these medicines can increase the risk of severe skin reactions and suppression of blood-cell production. Tell your doctor if you take co-trimoxazole, methotrexate or other medicines that affect folate.
Antifolate: medicine that blocks folate-dependent processes. Malaria parasite: Plasmodium organisms transmitted by infected mosquitoes. Sulfonamide: an antimicrobial medicine class. Sequential blockade: inhibition of successive steps in a biochemical pathway.; AR: Sulfamethoxazole 500mg + Pyrimethamine 25mg أقراص; FR: Sulfamethoxazole 500mg + Pyrimethamine 25mg comprimés; PT: Sulfamethoxazole 500mg + Pyrimethamine 25mg comprimidos; ES: Sulfamethoxazole 500mg + Pyrimethamine 25mg comprimidos; RU: Sulfamethoxazole 500mg + Pyrimethamine 25mg таблетки; ID: Sulfamethoxazole 500mg + Pyrimethamine 25mg tablet; VI: Sulfamethoxazole 500mg + Pyrimethamine 25mg viên nén; MS: Sulfamethoxazole 500mg + Pyrimethamine 25mg tablet; TL: Sulfamethoxazole 500mg + Pyrimethamine 25mg mga tableta; ZH-SG: Sulfamethoxazole 500mg + Pyrimethamine 25mg 片剂