Sulfadoxine 500mg + Pyrimethamine 25mg Tablets$28.00
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Sulfadoxine 500mg + Pyrimethamine 25mg Tablets
SKU GME1266Antiparasitic
Product Introduction
Sulfadoxine 500mg + Pyrimethamine 25mg is an antifolate antimalarial combination used for susceptible malaria parasites in an appropriate treatment regimen. The two ingredients act at successive steps in parasite folate metabolism.
How to use
Swallow the tablets with water after food to reduce stomach irritation. This medicine uses a specific short antimalarial regimen rather than a routine daily antibiotic schedule; the tablet count depends on the malaria regimen and body weight.
How it works
Sulfadoxine inhibits parasite dihydropteroate synthase, while pyrimethamine inhibits dihydrofolate reductase. The sequential block reduces folate needed for parasite growth.
Side effects
Nausea, vomiting, headache and rash may occur. Blistering rash, mouth sores, sore throat with fever or unusual bruising needs urgent attention because serious skin or blood reactions can occur.
Important information
Sulfonamide allergy, folate-deficiency blood disorders and significant liver or kidney disease affect suitability. Do not combine it casually with co-trimoxazole or other antifolate medicines.
Uses
- Treatment of susceptible malaria in a suitable antimalarial regimen.
Benefits
The complementary antifolate actions help clear susceptible parasites and control the infection responsible for malarial fever.
Can this be used for any fever?
No. Fever has many causes. Malaria testing and the likely parasite sensitivity determine whether an antimalarial regimen is appropriate.
Is this the same as co-trimoxazole?
No. Co-trimoxazole contains sulfamethoxazole and trimethoprim; this combination contains sulfadoxine and pyrimethamine.
What if a rash appears after the tablets?
Stop further doses and obtain urgent medical advice, especially with fever, mouth ulcers, eye irritation or skin blistering. Severe sulfonamide skin reactions can progress quickly.
Can I use it alone for severe malaria?
Severe illness, confusion, breathing difficulty, repeated vomiting or inability to drink needs urgent hospital treatment rather than reliance on an oral antifolate combination.
Does this tablet also contain artesunate?
No. Artesunate is a separate antimalarial. When a regimen includes artesunate with sulfadoxine-pyrimethamine, this tablet supplies only the two antifolate components.
Antifolate: medicine that blocks folate-dependent processes. Malaria parasite: Plasmodium organisms transmitted by infected mosquitoes. Sulfonamide: an antimicrobial medicine class. Sequential blockade: inhibition of successive steps in a biochemical pathway.; AR: Sulfadoxine 500mg + Pyrimethamine 25mg أقراص; FR: Sulfadoxine 500mg + Pyrimethamine 25mg comprimés; PT: Sulfadoxine 500mg + Pyrimethamine 25mg comprimidos; ES: Sulfadoxine 500mg + Pyrimethamine 25mg comprimidos; RU: Sulfadoxine 500mg + Pyrimethamine 25mg таблетки; ID: Sulfadoxine 500mg + Pyrimethamine 25mg tablet; VI: Sulfadoxine 500mg + Pyrimethamine 25mg viên nén; MS: Sulfadoxine 500mg + Pyrimethamine 25mg tablet; TL: Sulfadoxine 500mg + Pyrimethamine 25mg mga tableta; ZH-SG: Sulfadoxine 500mg + Pyrimethamine 25mg 片剂