Sitagliptin 100mg + Metformin Hydrochloride PR 500mg Tablets

Product Introduction

Sitagliptin 100mg + Metformin Hydrochloride PR 500mg combines sitagliptin with metformin for adults with type 2 diabetes as combination therapy. Sitagliptin improves glucose-dependent incretin signaling, while metformin lowers hepatic glucose production and improves insulin sensitivity. The combination targets fasting and post-meal glucose without simply repeating one mechanism. It is intended for type 2 diabetes, not type 1 diabetes or diabetic ketoacidosis.

How to use

Take Sitagliptin 100mg + Metformin Hydrochloride PR 500mg exactly as prescribed, usually with meals to improve metformin tolerability. Extended-release tablets should usually be swallowed whole. Kidney function should be checked as advised.

How it works

Sitagliptin inhibits DPP-4 to support incretin activity. Metformin lowers liver glucose output and improves insulin sensitivity.

Common side effects

Possible effects include nausea, diarrhea, abdominal discomfort, metallic taste, headache, and low blood sugar with insulin or sulfonylureas. Serious concerns include lactic acidosis, pancreatitis, allergic swelling, severe joint pain, kidney problems, bullous pemphigoid, and heart-failure symptoms.

Important information

Review eGFR, dehydration, severe infection, liver disease, heart failure, alcohol use, contrast imaging, surgery, pancreatitis history, pregnancy, breastfeeding, insulin, sulfonylureas, and extended-release swallowing instructions.