Fosfomycin Sodium 4g Injection$72.00
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Fosfomycin Sodium 4g Injection
SKU GME748Product Introduction
Fosfomycin sodium 4g is a parenteral antibiotic used for selected serious susceptible bacterial infections when usual initial antibiotics are unsuitable. It has a different role from the oral fosfomycin sachets used for certain bladder infections.
How to use
The hospital team reconstitutes and further dilutes the powder, then administers it by intravenous infusion. It is not taken by mouth or given as a rapid, undiluted injection. Kidney function, dialysis and infection severity determine the amount and interval between infusions.
How it works
Fosfomycin inhibits MurA, an enzyme needed at an early step of bacterial peptidoglycan synthesis. This disrupts formation of the bacterial cell wall.
Side effects
Nausea, diarrhoea, infusion-site inflammation and rash can occur. Low potassium, sodium overload, blood-cell abnormalities and severe allergic reactions are important potential effects.
Important information
Monitor kidney function, sodium, potassium and blood counts during treatment as appropriate. The sodium load matters in heart failure or fluid-sensitive illness. Severe persistent diarrhoea can indicate antibiotic-associated colitis and needs assessment.
Uses
- Selected complicated urinary, respiratory, bone, joint, bloodstream and other serious bacterial infections when culture results and the clinical setting support intravenous fosfomycin.
Benefits
Provides another cell-wall-active antibiotic option for difficult infections, including some resistant organisms, when susceptibility is demonstrated.
Can a 4g injection be replaced by a 3g oral sachet?
No. The salt, route, absorption and indications differ. Oral bladder-infection regimens do not provide an equivalent systemic treatment.
Is fosfomycin always used alone?
Not necessarily. Combination treatment is often considered for serious infections to improve coverage and limit selection of resistance.
How much sodium can a 4g dose contain?
A reference disodium-fosfomycin preparation supplies about 1.28g of sodium with a 4g fosfomycin dose. This sodium burden is clinically relevant in heart failure, oedema or a sodium-restricted treatment plan.
Why might potassium replacement be prescribed?
Intravenous fosfomycin can increase potassium loss. Replacement depends on measured levels and the patient's overall electrolyte balance.
Can it be used with kidney impairment?
It may be appropriate, but the dose and interval must reflect renal clearance and any dialysis treatment. A standard schedule should not simply be continued unchanged.
Does a culture report of resistance matter if symptoms improve?
Yes. The infection team should review susceptibility results and the whole clinical response before deciding to continue or change therapy.
Can every infusion fluid be used to dilute it?
No. The infusion fluid must be compatible with the supplied formulation. Some intravenous fosfomycin preparations are not compatible with sodium-chloride solutions, so the hospital pharmacy selects and prepares the diluent.
Is it suitable for an ordinary viral cough or cold?
No. Antibiotics do not treat viral respiratory infections, and an intravenous agent is not justified for an uncomplicated cold.
MurA: an enzyme involved in bacterial cell-wall synthesis. Peptidoglycan: structural material in bacterial cell walls. Susceptibility: whether an organism is expected to respond to an antibiotic. Hypokalaemia: low blood potassium. Sodium load: sodium delivered by a treatment.; AR: Fosfomycin Sodium 4g حقن; FR: Fosfomycin Sodium 4g injection; PT: Fosfomycin Sodium 4g injeção; ES: Fosfomycin Sodium 4g inyección; RU: Fosfomycin Sodium 4g инъекция; ID: Fosfomycin Sodium 4g injeksi; VI: Fosfomycin Sodium 4g thuốc tiêm; MS: Fosfomycin Sodium 4g suntikan; TL: Fosfomycin Sodium 4g iniksyon; ZH-SG: Fosfomycin Sodium 4g 注射剂