Avibactam 0.5g + Ceftazidime 2g Injection

Avibactam 0.5g + Ceftazidime 2g is an intravenous antibiotic combination for selected serious infections caused by susceptible Gram-negative bacteria. It can retain activity against some organisms resistant to other beta-lactam antibiotics.
The reconstituted dose is diluted and usually infused over two hours. Kidney function determines the dose and interval, and may need frequent reassessment during acute illness.
Ceftazidime inhibits bacterial cell-wall synthesis. Avibactam blocks several beta-lactamases, including some enzymes that would otherwise destroy ceftazidime.
Diarrhoea, nausea, vomiting, rash and infusion-site irritation can occur. Serious allergy, antibiotic-associated colitis and seizures from drug accumulation are important risks.
It does not cover every carbapenem-resistant organism. Culture and susceptibility findings are important, particularly when a metallo-beta-lactamase is suspected.
Provides a treatment option against selected resistant Gram-negative infections while susceptibility results guide appropriate use.
No. Avibactam does not inhibit metallo-beta-lactamases such as NDM on its own.
Additional anaerobic coverage can be needed because this combination does not provide reliable coverage of those organisms.
Rapidly changing kidney function changes drug clearance and can require prompt dose adjustments.
No. The organism and its susceptibility pattern determine whether the combination is suitable.
Gram-negative bacteria: a major group of bacteria. Beta-lactamase: an antibiotic-inactivating enzyme. Susceptibility: whether a bacterium is likely to respond to an antibiotic.; AR: Avibactam 0.5g + Ceftazidime 2g حقن; FR: Avibactam 0.5g + Ceftazidime 2g injection; PT: Avibactam 0.5g + Ceftazidime 2g injeção; ES: Avibactam 0.5g + Ceftazidime 2g inyección; RU: Avibactam 0.5g + Ceftazidime 2g инъекция; ID: Avibactam 0.5g + Ceftazidime 2g suntikan; VI: Avibactam 0.5g + Ceftazidime 2g thuốc tiêm; MS: Avibactam 0.5g + Ceftazidime 2g suntikan; TL: Avibactam 0.5g + Ceftazidime 2g iniksyon; ZH-SG: Avibactam 0.5g + Ceftazidime 2g 注射剂
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Avibactam 0.5g + Ceftazidime 2g Injection