Prochlorperazine 12.5mg/1mL Injection

Product Introduction

Prochlorperazine 12.5mg/1mL is an injectable phenothiazine antiemetic and vestibular suppressant used under medical supervision for nausea, vomiting, and vertigo for prochlorperazine treatment. In some settings it is also used for acute severe agitation or psychotic symptoms, but indication and dosing differ. Prochlorperazine blocks dopamine receptors in the brain's vomiting center and vestibular pathways, helping reduce nausea and dizziness related to inner-ear disorders such as Meniere's disease. Because it can cause sedation, low blood pressure, extrapyramidal reactions, dystonia, akathisia, parkinsonism, and rarely neuroleptic malignant syndrome, injection should be given with observation. Important risks include QT prolongation or arrhythmia, severe drowsiness, anticholinergic effects, jaundice, blood-count problems, and injection-site reactions.

How to use

Prochlorperazine 12.5mg/1mL is given by a healthcare professional by the prescribed route. The patient should be monitored for drowsiness, low blood pressure, abnormal movements, and symptom response.

How it works

Prochlorperazine blocks dopamine receptors involved in vomiting and vestibular signaling, reducing nausea, vomiting, and vertigo symptoms.

Common side effects

Possible effects include drowsiness, dizziness, dry mouth, constipation, low blood pressure, blurred vision, and injection-site reactions. Serious concerns include dystonia, severe restlessness, parkinsonism, QT prolongation, arrhythmia, neuroleptic malignant syndrome, jaundice, and severe allergy.

Important information

Review Parkinson's disease, dementia, glaucoma, prostate enlargement, seizures, liver disease, heart rhythm disease, low potassium/magnesium, pregnancy, breastfeeding, alcohol, sedatives, anticholinergics, and QT-prolonging medicines.