Nalbuphine 10mg/mL Injection

Product Introduction

Nalbuphine 10mg/mL Injection is an injectable opioid agonist-antagonist analgesic used for moderate to severe pain for nalbuphine treatment. It may also be used as part of anesthesia-related pain management by trained clinicians. Nalbuphine can relieve pain through kappa-opioid agonist activity and mu-opioid antagonist activity, but it is still an opioid and can cause sedation, respiratory depression, dependence, misuse, and withdrawal problems. Nalbuphine can precipitate withdrawal in people physically dependent on full opioid agonists such as morphine, oxycodone, heroin, fentanyl, or methadone. Combining it with alcohol, benzodiazepines, sleeping pills, muscle relaxants, antipsychotics, gabapentinoids, or other opioids increases sedation and breathing-risk concerns.

How to use

Nalbuphine 10mg/mL Injection is given by healthcare professionals by IV, IM, or subcutaneous route as prescribed. Do not self-inject. Monitoring should include pain relief, sedation, breathing, blood pressure, and withdrawal symptoms.

How it works

Nalbuphine acts as a kappa-opioid receptor agonist and mu-opioid receptor antagonist, producing analgesia while limiting some mu-opioid effects.

Common side effects

Possible effects include sleepiness, dizziness, nausea, vomiting, sweating, dry mouth, headache, constipation, and injection-site discomfort. Serious concerns include slow breathing, severe low blood pressure, profound sedation, withdrawal, seizures, allergic reaction, and misuse or dependence.

Important information

Review opioid dependence, recent opioid use, respiratory disease, sleep apnea, head injury, low blood pressure, liver/kidney disease, biliary disease, pregnancy, breastfeeding, alcohol, benzodiazepines, sedatives, gabapentinoids, antidepressants, and MAOIs.