Bupivacaine Hydrochloride 0.25% w/v, 20mL Injection

Product Introduction

Bupivacaine Hydrochloride 0.25% w/v Injection, 20mL is an injectable amide local anaesthetic used by trained clinicians for local or regional anaesthesia and analgesia. Plain bupivacaine solutions such as 0.25% and 0.5% may be selected for infiltration, peripheral nerve block, caudal block, epidural block, or other approved regional techniques depending on concentration and procedure. Bupivacaine numbs nerves by stopping sodium-channel conduction, producing longer-lasting pain relief or surgical anaesthesia than many shorter-acting local anaesthetics. The 0.25% concentration is often chosen when less dense motor block is acceptable, while 0.5% may provide stronger block for selected procedures.

How to use

Bupivacaine Hydrochloride 0.25% w/v Injection, 20mL is injected only by trained healthcare professionals using the correct regional-anaesthesia technique. Monitoring should be available for blood pressure, heart rhythm, breathing, block level, and symptoms of toxicity. It should not be self-administered.

How it works

Bupivacaine blocks voltage-gated sodium channels in nerves. This prevents pain signals and other nerve impulses from travelling through the blocked area for a temporary period.

Common side effects

Possible effects include numbness beyond the intended area, weakness, low blood pressure, slow heart rate, nausea, dizziness, tingling around the mouth, ringing in ears, metallic taste, or drowsiness. Serious toxicity can cause seizures, heart rhythm problems, cardiac arrest, high spinal block, nerve injury, or severe allergy.

Important information

Use only where resuscitation equipment and trained staff are available. Caution is needed in heart disease, liver disease, pregnancy, older adults, frail patients, low blood volume, infection at injection site, coagulation disorders for neuraxial use, and concurrent local anaesthetics or antiarrhythmic medicines.