Trimethoprim 160mg + Sulfamethoxazole 800mg Tablets

Product Introduction

Trimethoprim 160mg + Sulphamethoxazole 800mg is a fixed-dose antibiotic combination of sulfamethoxazole and trimethoprim, often called co-trimoxazole. It is used for susceptible bacterial infections such as urinary-tract infection, respiratory infection, certain gastrointestinal infections, and selected Pneumocystis jirovecii pneumonia treatment or prevention depending on the patient and local guidance. The two components block sequential steps in bacterial folate synthesis, giving broader antibacterial activity than either component alone. It should be used only for proven or strongly suspected susceptible infections. Interaction review is important with warfarin, methotrexate, phenytoin, ACE inhibitors, ARBs, spironolactone, diuretics, and other medicines affecting potassium, blood counts, kidneys, or bleeding.

How to use

Take Trimethoprim 160mg + Sulphamethoxazole 800mg exactly as prescribed with water. Keep the full duration, avoid unnecessary sun exposure, and report rash or severe diarrhea promptly.

How it works

Sulfamethoxazole and trimethoprim inhibit two sequential bacterial folate steps, reducing DNA synthesis and bacterial growth.

Common side effects

Possible effects include nausea, vomiting, appetite loss, rash, itching, photosensitivity, and diarrhea. Serious concerns include severe skin reactions, blood disorders, high potassium, kidney injury, liver injury, C. difficile diarrhea, and allergy.

Important information

Review sulfa allergy, kidney/liver disease, folate deficiency, blood disorders, G6PD deficiency, pregnancy, breastfeeding, potassium level, warfarin, methotrexate, phenytoin, ACE inhibitors, ARBs, spironolactone, and diuretics.