Safinamide 50mg Tablets$48.00
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Safinamide 50mg Tablets
SKU GME703Product Introduction
Safinamide 50mg is a selective MAO-B inhibitor added to levodopa-based treatment for Parkinson's disease when motor fluctuations occur. It helps reduce periods when the effect of levodopa wears off.
How to use
Take once daily at a consistent time, with or without food, as part of the established levodopa regimen. Dose selection depends on response, liver function and interacting medicines.
How it works
Reversible inhibition of monoamine oxidase B slows dopamine breakdown; modulation of sodium channels and glutamate release may also contribute.
Side effects
Dyskinesia, nausea, insomnia, dizziness and falls may occur.
Important information
Tell your doctor if you take antidepressants or other serotonergic medicines, another MAO inhibitor, an opioid or a decongestant/stimulant. Severe liver impairment is a contraindication. Increased involuntary movements or hallucinations may require adjustment of the overall Parkinson's treatment.
Uses
- Adjunctive treatment of fluctuating Parkinson's disease with levodopa
Benefits
Can increase useful motor-control time and reduce wearing-off periods.
Does it replace levodopa?
No. It is an add-on to a levodopa-based regimen.
What is wearing off?
It is the return of motor symptoms before the next levodopa dose takes effect.
Can involuntary movements increase?
Yes. Greater dopaminergic activity may worsen dyskinesia and require regimen adjustment.
Can I use another MAO inhibitor with it?
No. The prescriber must manage incompatible combinations and washout periods.
Can cough medicines interact?
Avoid dextromethorphan-containing cough suppressants while taking safinamide unless the specialist has specifically reviewed the combination. Interactions can cause serious changes in behaviour or nervous-system effects. Cold remedies containing pseudoephedrine or ephedrine can also raise blood pressure.
Is a strict low-tyramine diet always needed?
A strict low-tyramine diet is not routinely required at the recommended 50mg or 100mg daily dose. Avoid foods with very high tyramine content, such as large amounts of strongly aged cheese, because they can cause a dangerous rise in blood pressure.
Does liver disease change treatment?
Yes. Moderate impairment limits dosing and severe impairment makes use unsuitable.
Should new hallucinations be reported?
Yes. They can reflect dopaminergic adverse effects and need assessment.
MAO-B: an enzyme involved in dopamine breakdown. Off time: a period of reduced response to Parkinson's treatment. Dyskinesia: involuntary movement.; AR: Safinamide 50mg أقراص; FR: Safinamide 50mg comprimés; PT: Safinamide 50mg comprimidos; ES: Safinamide 50mg comprimidos; RU: Safinamide 50mg таблетки; ID: Safinamide 50mg tablet; VI: Safinamide 50mg viên nén; MS: Safinamide 50mg tablet; TL: Safinamide 50mg tableta; ZH-SG: Safinamide 50mg 片剂