Rosuvastatin 10mg + Ezetimibe 10mg Tablets

Product Introduction

Rosuvastatin 10mg + Ezetimibe 10mg is a lipid-lowering combination used when greater LDL cholesterol reduction is needed than one component alone can provide. It combines reduced cholesterol synthesis with reduced intestinal cholesterol absorption.

How to use

Take with or without food at a consistent daily time. If a bile-acid sequestrant is also used, take this combination at least two hours before or four hours after it. Lipid tests show whether the intended reduction has been achieved.

How it works

Rosuvastatin inhibits hepatic cholesterol synthesis and increases LDL clearance. Ezetimibe blocks NPC1L1-mediated cholesterol absorption in the intestine, reducing cholesterol delivery to the liver.

Side effects

Headache, abdominal discomfort, diarrhoea and muscle aches may occur. Severe weakness, dark urine, jaundice or facial swelling needs prompt assessment.

Important information

Liver disease, kidney impairment and untreated hypothyroidism affect risk. Ciclosporin and some antivirals can increase exposure. Other statins or fibrates should not be added casually because muscle toxicity can increase.