Propranolol 40mg + Flunarizine 10mg Tablets

Product Introduction

Propranolol 40mg + Flunarizine 10mg combines propranolol with flunarizine for migraine prevention when a clinician wants both beta-blocker and calcium-channel-blocking preventive effects. It is not used to treat a migraine attack that has already started. Propranolol reduces beta-adrenergic stimulation and may reduce migraine frequency through vascular and nervous-system effects. Flunarizine helps stabilize neuronal excitability and vascular responses involved in migraine susceptibility. The combination may be considered when recurrent migraine attacks need prevention, but it requires careful review because both components can cause tiredness, dizziness, sleepiness, low blood pressure, and mood or neurologic effects. Flunarizine can cause weight gain, increased appetite, depression, extrapyramidal symptoms, and parkinsonism, especially with longer use or in susceptible patients. Propranolol can slow pulse, worsen bronchospasm in asthma, mask hypoglycemia warning signs, and aggravate heart block or uncontrolled heart failure.

How to use

Take Propranolol 40mg + Flunarizine 10mg exactly as prescribed for migraine prevention. It is usually taken regularly, not during an acute attack. Avoid driving if sleepy or dizzy and report mood or movement changes.

How it works

Propranolol blocks beta receptors and flunarizine modulates calcium-channel-related neuronal and vascular activity, together reducing migraine susceptibility in selected patients.

Common side effects

Possible effects include tiredness, dizziness, sleepiness, slow pulse, low blood pressure, nausea, weight gain, increased appetite, dry mouth, and mood change. Serious concerns include bronchospasm, severe bradycardia, depression, parkinsonism, abnormal movements, worsening heart failure, and allergic reaction.

Important information

Review asthma/COPD, heart block, slow pulse, heart failure, diabetes, depression, Parkinson's disease, movement disorder, obesity/weight gain concerns, pregnancy, breastfeeding, alcohol, sedatives, antiarrhythmics, and calcium-channel blockers.