Pioglitazone 15mg + Metformin 500mg Tablets$46.00
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Pioglitazone 15mg + Metformin 500mg Tablets
SKU GME393Product Introduction
Pioglitazone 15mg + Metformin 500mg ER combines pioglitazone with extended-release metformin for adults with type 2 diabetes for both medicines. Pioglitazone improves insulin sensitivity, while metformin reduces hepatic glucose production and improves insulin use. This combination is not for type 1 diabetes or diabetic ketoacidosis.
How to use
Take Pioglitazone 15mg + Metformin 500mg ER as prescribed, usually with food. Swallow extended-release tablets whole if applicable. Kidney function, glucose response, swelling, and gastrointestinal tolerance should be reviewed.
How it works
Pioglitazone improves insulin sensitivity through PPAR-gamma activation. Metformin lowers hepatic glucose production and improves insulin-mediated glucose use.
Common side effects
Possible effects include nausea, diarrhea, abdominal discomfort, metallic taste, weight gain, swelling, headache, and low blood sugar with insulin or sulfonylureas. Serious concerns include lactic acidosis, heart failure, liver injury, severe dehydration, macular edema, and allergic reaction.
Important information
Review kidney function, eGFR, heart failure, edema, liver disease, alcohol use, dehydration, iodinated contrast imaging, surgery, bladder-cancer history, pregnancy, breastfeeding, insulin, sulfonylureas, gemfibrozil, and rifampicin.
Uses
Type 2 diabetes mellitus in adults when a pioglitazone plus metformin extended-release combination is prescribed.
Benefits
Targets insulin resistance and excess liver glucose production in one tablet, supporting glucose control in type 2 diabetes.
What is Pioglitazone 15mg + Metformin 500mg ER used for?
Pioglitazone 15mg + Metformin 500mg ER is used for type 2 diabetes to improve blood-sugar control with two complementary actions.
Why check kidney function?
Metformin safety depends on kidney function, and impaired kidney function can increase lactic-acidosis risk.
Why watch for swelling?
Pioglitazone can cause fluid retention, which can worsen or trigger heart failure.
Can the ER tablet be crushed?
Extended-release tablets are usually swallowed whole unless the prescriber or label says otherwise.
When is urgent review needed?
Severe dehydration, slow breathing, unusual muscle pain, extreme weakness, rapid weight gain, breathlessness, or jaundice need urgent review.
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