Neostigmine Methyl Sulphate 0.5mg/mL Injection$42.00
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Neostigmine Methyl Sulphate 0.5mg/mL Injection
SKU GME728Product Introduction
Neostigmine Methyl Sulphate 0.5mg/mL Injection is an injectable acetylcholinesterase inhibitor used for selected reversal of non-depolarising neuromuscular blockade and other specialist indications. Safe use depends on neuromuscular recovery and the clinical setting.
How to use
A trained team administers the injection by the indication-specific labelled route. For anaesthetic reversal, monitor neuromuscular function and give the planned antimuscarinic, such as glycopyrrolate or atropine, to limit muscarinic effects.
How it works
Inhibition of acetylcholinesterase increases acetylcholine at neuromuscular and autonomic synapses, helping overcome susceptible non-depolarising blockade.
Side effects
Bradycardia, increased saliva or bronchial secretions, abdominal cramps, nausea and diarrhoea may occur.
Important information
Mechanical gastrointestinal or urinary obstruction is a contraindication. Excess exposure can cause cholinergic weakness, bronchospasm or severe bradycardia; ventilatory support and monitoring must remain available.
Uses
- Selected reversal of non-depolarising neuromuscular blockade
- other labelled specialist cholinergic indications
Benefits
Can restore neuromuscular transmission during appropriate recovery from susceptible anaesthetic muscle relaxants.
Why is glycopyrrolate or atropine often given with reversal?
It limits bradycardia and other muscarinic effects while neuromuscular recovery is promoted.
Does it reverse every muscle relaxant?
No. It is used for appropriate non-depolarising blockade and can be unsuitable for other situations.
Can too much cause weakness?
Yes. Excess acetylcholine can cause cholinergic weakness rather than better recovery.
Why use neuromuscular monitoring?
The depth of blockade and recovery determine whether reversal will be effective and safe.
Can it treat a mechanical bowel obstruction?
No. Increasing bowel activity against an obstruction is unsafe.
Does it remove the need for breathing support?
No. Ventilation must be supported until adequate recovery is demonstrated.
Can asthma or bronchospasm matter?
Yes. Increased cholinergic activity can worsen airway constriction and secretions.
Is it the same as sugammadex?
No. Their mechanisms, blocker compatibility and safety considerations differ.
Acetylcholinesterase: an enzyme that breaks down acetylcholine. Non-depolarising blockade: muscle paralysis from competitive neuromuscular blockers. Antimuscarinic: a medicine that reduces muscarinic cholinergic effects.; AR: Neostigmine Methyl Sulphate 0.5mg/mL حقن; FR: Neostigmine Methyl Sulphate 0.5mg/mL injection; PT: Neostigmine Methyl Sulphate 0.5mg/mL injeção; ES: Neostigmine Methyl Sulphate 0.5mg/mL inyección; RU: Neostigmine Methyl Sulphate 0.5mg/mL инъекция; ID: Neostigmine Methyl Sulphate 0.5mg/mL injeksi; VI: Neostigmine Methyl Sulphate 0.5mg/mL thuốc tiêm; MS: Neostigmine Methyl Sulphate 0.5mg/mL suntikan; TL: Neostigmine Methyl Sulphate 0.5mg/mL iniksyon; ZH-SG: Neostigmine Methyl Sulphate 0.5mg/mL 注射剂