Metolazone 5mg Tablets

Product Introduction

Metolazone 5mg is a thiazide-like diuretic used for fluid retention associated with heart failure or kidney disease and, in selected patients, high blood pressure. It increases renal salt and water removal.

How to use

Take in the morning to limit night-time urination. When combined with a loop diuretic, the schedule is deliberately coordinated because diuresis can become substantial. Track weight and symptoms, with blood tests for kidney function and electrolytes.

How it works

Metolazone inhibits sodium reabsorption in the distal nephron. More sodium and water are excreted, reducing extracellular fluid volume and oedema.

Side effects

Increased urination, dizziness, dehydration, low sodium, low potassium and raised uric acid can occur. Confusion, severe weakness, palpitations or very low urine output needs prompt assessment.

Important information

Combination with loop diuretics can cause profound fluid and electrolyte loss. Gout, diabetes and kidney or liver disease are important. Lithium can accumulate and NSAIDs can reduce diuretic response. Increasing the dose based on swelling alone can be unsafe without laboratory assessment.