Leucovorin Calcium 15mg Tablets

Product Introduction

Leucovorin Calcium 15mg is a folinic acid medicine used in specific oncology and hematology settings. It is not the same as routine folic acid supplementation and should not be used casually to self-treat anemia or mouth ulcers without diagnosis. Timing is critical in methotrexate rescue because delayed or inadequate leucovorin can lead to serious toxicity, while excessive or mistimed use can interfere with methotrexate efficacy. When used with fluorouracil, gastrointestinal toxicity and bone marrow suppression can be more severe, especially in older or frail patients.

How to use

Take Leucovorin Calcium 15mg exactly on the schedule prescribed. Do not delay, skip, or change timing during methotrexate rescue. Keep required blood tests and oncology follow-up.

How it works

Leucovorin is reduced folate. It rescues normal cells from folate-antagonist toxicity and can also enhance fluorouracil binding to thymidylate synthase in some cancer regimens.

Common side effects

Possible effects include nausea, vomiting, diarrhea, rash, sleep disturbance, and allergic reactions. With fluorouracil, severe diarrhea, mouth sores, low blood counts, and dehydration can occur.

Important information

Review methotrexate schedule, kidney function, hydration, cancer regimen, fluorouracil use, seizure medicines, pregnancy, breastfeeding, anemia type, folate/B12 status, infection symptoms, diarrhea, and medication timing.