Hydroxyprogesterone Caproate 500mg/2mL Injection$48.00
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Hydroxyprogesterone Caproate 500mg/2mL Injection
SKU GME593Product Introduction
Hydroxyprogesterone caproate is a long-acting injectable progestogen. It has been used for amenorrhoea, hormone-related abnormal uterine bleeding and selected advanced endometrial cancers in non-pregnant women. Its clinical roles differ from those of natural progesterone.
How to use
A clinician gives this oily, long-acting preparation by deep intramuscular injection. The listed 500mg in 2mL is equivalent to 250mg/mL. It is not for intravenous use and cannot replace vaginal progesterone or a subcutaneous hydroxyprogesterone formulation. Injection intervals differ by treatment indication rather than by ampoule size.
How it works
It binds progesterone receptors and produces progestogenic effects in hormone-responsive tissues.
Side effects
Injection-site pain, swelling, itching, nausea and headache may occur; thrombosis and significant allergic reactions are serious concerns.
Important information
Tell your doctor about previous blood clots, liver disease, unexplained vaginal bleeding, hormone-sensitive cancer, diabetes or depression. Confirmatory studies did not show a benefit in preventing recurrent preterm birth. Exposure in the womb has also been associated with a possible, unconfirmed long-term cancer risk in the child.
Uses
- Amenorrhoea and abnormal uterine bleeding caused by hormonal imbalance in non-pregnant women after organic causes have been excluded. Specialist palliative treatment of selected advanced adenocarcinoma of the uterine corpus.
Benefits
Can produce a sustained progestogenic response in the uterine lining in selected hormonal menstrual disorders. Its role in advanced endometrial cancer is palliative; a tumour response is not guaranteed.
Is it the same as natural progesterone?
No. Hydroxyprogesterone caproate is a different molecule with different evidence and administration schedules.
Has hydroxyprogesterone caproate been shown to prevent recurrent preterm birth?
No. Confirmatory studies did not demonstrate a benefit for preventing recurrent preterm birth or complications of prematurity in newborns.
Does it treat every cause of irregular or absent periods?
No. Pregnancy and non-hormonal causes of bleeding or absent periods need assessment before a hormonal treatment is selected.
Can it be substituted for a vaginal progesterone product?
No. Route, molecule and indication are different.
What symptoms could suggest a blood clot?
One-sided leg swelling, sudden chest pain or unexplained shortness of breath requires emergency assessment.
Can it treat unexplained bleeding without investigation?
No. Unexplained genital bleeding needs a diagnosis before hormonal treatment.
Does the 500mg strength establish a weekly schedule?
No. A schedule cannot be inferred solely from the strength.
Does evidence for natural progesterone apply to this injection?
No. Oral or vaginal progesterone and hydroxyprogesterone caproate are different medicines. Results for one formulation cannot be transferred to another molecule or route.
Progestogen: a substance with progesterone-like effects. Caproate: an ester producing prolonged action. Confirmatory trial: a study intended to verify clinical benefit., AR: Hydroxyprogesterone / حقن, FR: Hydroxyprogesterone /, PT: Hydroxyprogesterone / injeção, ES: Hydroxyprogesterone / inyección, RU: Hydroxyprogesterone / инъекция, ID: Hydroxyprogesterone / injeksi, VI: Hydroxyprogesterone / thuốc tiêm, MS: Hydroxyprogesterone / suntikan, TL: Hydroxyprogesterone / iniksyon, ZH-SG: Hydroxyprogesterone / 注射剂